Currently: Reader in Psychiatry & Consultant Psychiatrist
RESEARCH GRANTS & AWARDS
• Co-applicant: 2015-2017: (Lead investigator Into Qurashi) A placebo controlled double blind randomised trial of hyoscine hydrobromide and glycopyrrolate in the treatment of clozapine induced hypersalivation. NIH-R, Research for Patient Benefit Programme (RfPB) (£243,000).
• Co-applicant: 2015-2018: (Lead investigator Inti Qurashi). A randomised double blind placebo controlled pilot study of minocycline and/or Omega-3 fatty acids added to treatment as usual for At Risk Mental State. Stanley Medical Research Institute (SMRI) ($298240).
• Lead applicant: 2015-2016: Exploratory randomised controlled trial of a culturally adapted psychological intervention for the management of Irritable Bowel Syndrome (IBS) in a low-income country Pakistan Institute of Learning and Living. (£10,000).
• Lead applicant: 2014-2015: Development and testing of a Mobile Phone based Intervention to Reduce Postnatal Depression and Improve Child Health. Key objective is to test the efficacy of an innovative, affordable mobile based intervention program that can help mothers with postnatal depression in low resource country like Pakistan. . Pakistan Institute of Learning and Living. (£12,000).
• Lead applicant: 2014-2015: Minocycline as an adjunct for the treatment of resistant Depression Pilot Study. Kings College and Pakistan Institute of Learning and Living. (£15,000).
• Co-applicant: 2013-2015: (Lead investigator Imran Chaudhry). Role of methotrexate as an adjunct to routine treatment in Schizophrenia, a randomised placebo controlled double blind pilot study. Stanley Medical Research Institute (SMRI) ($155,000).
• Co-applicant: 2013-2015: (Lead investigator Batool Fatima) Grand Challenges Canada, Global Mental Health Seed Grant (Ca$ 249,000). Participatory intervention to reduce maternal depression and under five child morbidity– A cluster-randomized controlled trial.
• Lead Applicant 2013-2015: NHS S&F (£35,000), 2013-2015. Use of mobile phone technology to improve access to services in Early Intervention for Psychosis Service: a feasibility study.
• Collaborator: 2013-2016. (Lead investigator Dawn Edge) Culturally-adapted Family Intervention (CaFI) for African Caribbeans with schizophrenia and their families: A feasibility study of implementation and acceptability. £351,923.90 NIH-R (HS&DR)
• Co-applicant: 2014-2017. (Lead investigator Nicola Lowe) Improving Maternal Health and reducing Child Mortality through Developing Health Service Delivery for the Poor and Marginalised Community of Baghbanan, North West Pakistan. DFID £365,743
• Co- Applicant: 2012-2016. (Lead invetigator Professor Bill Deakin). The benefits of Minocycline on negative symptoms in schizophrenia: Extent and Mechanisms. MRC-NIH-R EME Programme Grant (£1,790,923).
• Co-Lead Lancashire Site (PI Lancashire Site 2011-2015: M Marshall Chief Investigator Max Birchwood) Sustaining Positive Engagement and Recovery (SuperEDEN) – the next step after early Intervention for Psychosis. NIHR (Programme Grant; £1,994,933).
• Lead Applicant: 2011 – 2013. Exploratory RCT of a group psychological Intervention for Postnatal Depression in British Mothers of Pakistani Origin NIH-R RfPB (£249650).
• Co-Applicant: 2011-2013. Lead applicant Dr Fiona Lobban Ca-REACT – Culturally adapted Relatives’ Education and Coping Toolkit: Cultural adaptation study will explore how existing interventions for relatives of people with recent onset psychosis need to be adapted to meet the needs of the South Asian population. NHS S&F (£30,000).
• Lead Applicant (Pakistan): 2010 – 2013. Lead Applicant Prof Imran Chaudhry Randomised double blind placebo controlled study of Ondansetron and Simvastatin added to treatment as usual in patients with schizophrenia in Pakistan and Brazil. Stanley Medical Research Institute (SMRI) ($359560).
• Lead Applicant: 2009-2013. Exploratory RCT of culturally adapted brief psychological intervention in females of South Asian family origin suicide attempters treated in the emergency department. NHS S&F (£15000).
• Co- Applicant: 2007-2013. The H.E.L.P.E.R. Programme (HEalthy Living and Prevention of Early Relapse). The proposed programme focuses on developing interventions to target known risk factors for relapse and poor health, in young people with early psychosis. The interventions are linked by a common theoretical framework, the Self-regulatory Model of Illness Management and will be designed for optimum delivery by the national network of Early Psychosis Teams. My role is to ensure that the interventions are culturally sensitive to the participants of South Asian origin. NIH-R Programme Grant (£1,439,470)
Locally Funded Research Projects in Pakistan: (Approximately £45,000)
Lead applicant: Randomised rater blind pilot study of Minocycline and placebo added to Clozapine in treatment resistant schizophrenia. .
Lead applicant: Depressive symptoms and outcomes in Pakistani patients with heart failure: In this study we aim to determine the prevalence of depression and its relationship to major outcomes in patients hospitalized with congestive heart failure.
Lead applicant: Gene X Environment & Adult Depression in Pakistan. Considering the multifactorial aetiology of depression and the complex interplay of environmental and genetic factors in its onset, our objectives of the research are to explore the relationship between these factors.
Co-Applicant. 2010-2012. (Lead applicant Dr Imran Chaudhry). Improving access to psychosocial therapies for severe mental illness within the Pakistan mental health services. British Council International Health Links Funding Scheme (£29,820).
a) Chief Investigator: Feasibility RCT of culturally adapted Cognitive Behaviour Therapy (CBT) for Psychosis in Pakistan.
b) Chief Investigator: Feasibility RCT of culturally adapted Family Intervention (FI) for psychosis in Pakistan.
c) Chief Investigator: Feasibility RCT of culturally adapted Cognitive Behaviour Therapy (CBT) for bipolar disorder in Pakistan.
Principal Applicant: 2008-2010: Prime Ministers Initiative for International Education 2 (PMI2) Department of Innovation & Universities & Skills (Managed by the British Council) (£37,206). University of Manchester-Dow University of Health Sciences: Randomised Control Trial of a complex intervention for postnatal depression. This is an initiative from the UK Higher Educational Institutions to support capacity building in low income countries. Over the years, these initiatives from the UK have contributed significantly to the improvement of global health.
Co-Lead Lancashire Site (Lead Lancashire Site 2005-2009): (PI: M Marshall Chief Investigator Max Birchwood) A National Evaluation of Early Intervention for Psychosis Services: DUP, Service Engagement and Outcome. This study aimed to evaluate the implementation and impact on key outcomes of somewhat differently configured Early Intervention Services (EIS) across sites in England and to develop a model of variance in patient outcomes that included key variables of duration of untreated psychosis (DUP), fidelity to the EIS model and service engagement. Programme Grant DoH £1,640,000.
Principal Applicant. 2008-20011 Implementation & further evaluation of an Early Child Development Intervention (Learning Through Play). This is a CIDA funded project (Ca$60,000), which is being carried out with the collaboration of Hincks Delcrest Centre Toronto Canada. It is a population-based study in an urban area of Pakistan. The study is a randomised controlled trial to assess the efficacy of a parent based intervention on the physical development of failure to thrive infants of depressed mothers.
Co-Applicant. 2008-20011 Implementation & further evaluation of an Early Child Development Intervention (Learning Through Play). This is a CIDA funded project (Ca$30,000), which is being carried out with the collaboration of Hincks Delcrest Centre Toronto Canada. It is a population-based study in a rural area of Kenya. The study is a randomised controlled trial to assess the efficacy of a parent based intervention on the physical development of infants of depressed mothers.
Co-Applicant: 2009-2010. Role of Anti-Inflammatory Agents in Patients with Schizophrenia. .A feasibility study in patients with chronic schizophrenia to explore the adjunct use of simvastatin and ondansetron on positive, negative and general psychopathology. Neuroscience and Psychiatry Unit University of Manchester and Pakistan Institute of Learning and Living (£10,000).
Principal Investigator: 2005-2008 MRC Brain Sciences Initiative – Pathfinder (Ref: G0401084): £249,000) Pre & postnatal depression and infant growth in women and infants of Pakistani origin in Manchester.
Principal Applicant: 2006-2008: A study of factors influencing the duration of untreated psychosis (DUP) in Pakistan. The aims are to study the pathways to care and symptomatology influencing the DUP, and influence of DUP on short term outcomes. The study is funded by Pakistan Institute of Learning and Living. (Ca$10000).
Co-Investigator: 2005-2007 Randomised rater blind pilot study of minocycline and placebo added to treatment as usual (TAU) in first episode psychosis. This was a Stanley funded project ($185000).
Principal Investigator. 2004-2007 Implementation & further evaluation of an Early Child Development Intervention (Learning Through Play). This is a CIDA funded project (Ca$30,000), which is being carried out with the collaboration of Dell Crest Hincks Centre Toronto Canada. It is a population-based study in an urban area of Pakistan. The study is a randomised controlled trial to assess the efficacy of a parent based intervention on the development of infants.
Co-Investigator: RCT of a complex intervention of persistently depressed women of Pakistani origin. This is a MRC funded project (£192,000) We aim to test the hypothesis that chronically depressed Pakistani women, the beneficial effects on severity of depression and social functioning of 1) social group therapy including psycho-education exceed protocol guided antidepressant treatment, and that 2) combined social therapy group with protocol guided antidepressant treatment exceed social therapy alone.
Principal Investigator: Irritable Bowel Syndrome in a non-Western population: Prevalence, Depressive Symptoms and Health Care Seeking Behaviour. The Study was funded by University of Manchester & Pakistan Institute of Learning and Living (£4100). This is a population-based study involving a house-to-house survey. The survey has been conducted in Arafat Town, which is in Karachi, the largest city of Pakistan. The total population of Arafat Town is 15,000. A sample of one thousand adults was randomly chosen from the electoral register using random number tables.
Principal Investigator. Depressive symptoms and birth outcomes in a low income country.
The purpose of this exploratory study is to compare the depressive symptoms and birth outcomes of women attending a charitable clinic in Pakistan. This project is funded by the Pakistan Institute of Learning and Living, Karachi ($10,000).
Co-Investigator. Amoxapine as an atypical antipsychotic: A comparative study vs. haloperidol. A double blind flexible dose study of amoxapine vs. haloperidol as a treatment for patients with schizophrenia. In collaboration with School of Psychiatry and behavioural Sciences, University of Manchester and the Schizophrenia Program and the department of Psychiatry, University of Toronto (£12000).
Principal Investigator. Case-Control Study of Suicide by immigrant/foreign born psychiatric patients. The study has examined the complete series of caseload of completed suicides at the Clarke Division of Centre of Addiction and Mental Health University of Toronto Canada over the period from 1966 to 1997.
Principal Investigator. Dow Medical College Karachi – Medical Outpatient Survey.
The study was funded by Pakistan Institute of Learning & Living (£2100). This was in collaboration with School of Psychiatry & Behavioural Sciences University of Manchester U.K this study assessed the SRQ scores compared to other population-based studies and also whether the SRQ scores were significantly higher in those patients who do not have a definite organic diagnosis to explain their symptoms.
Principal Investigator. Evaluation of an Early Child Development Intervention (Learning Through Play).This was a CIDA funded project (Ca$35,000), which was carried out with the collaboration of Dell Crest Hincks Centre Toronto Canada. It was a population-based study in rural areas of Rawalpindi district Pakistan. The study was a randomised controlled trial to assess the efficacy of a parent based intervention on the physical and cognitive development of a child in the first year of life.
Industry Funded Research:
• 2012 – 2015: Co-Investigator: Clinical Trial. A Randomised double blind, placebo-controlled, dose-ranging, parallel group, group-sequential phase 2 study of safety and efficacy of ABT-126 in the treatment of cognitive deficits in schizophrenia in non-smokers. Abbott pharmaceutical funded MHRN supported study.
• 2010 – 2013: Chief Investigator Lancashire: Clinical Trial. Observational assessment of safety in Seroquel (OASIS). Astra Zeneca funded MHRN supported study.
International: Oral Presentations:
• Symposium Chair Husain N: Culturally Adapted Psychiatric and Psychosomatic Strategies- Experiments and Experiences. EAPM Sibiu 2014
Speaker: Husain N: Culturally Adapted Psychosocial Interventions: Increasing access for British South Asians. Manchester Medical Society, Manchester 2014
- Speaker: Husain N: Innovations in treatment of postnatal depression: Focus on British South Asians, Annual meeting Dow Graduates Association of Northern Europe, 2014
- Chair workshop: Enhancing Cultural Competence: Challenges, 16th World Congress of Psychiatry-Focusing on Access Quality and Human care, Madrid 2014
Invited Speaker: Husain N: Culturally adapted Psychological Interventions: Lessons from UK. Pakistan Association of Cognitive Behaviour Therapists (PACT) 4th International Conference. Karachi 2013
• Speaker: Husain N: Culturally adapted CBT: Focus on depression EACP Marrakesh 2013
• Speaker: Rathod S & Husain N: Delivering culturally adapted CBT to ethnic minorities. EACP Marrakesh 2013
• Speaker: Husain N: Is CBT a model of treatment for mental health problems that can be applied across cultures & contexts? BACP London 2013
• Invited Speaker: Husain N: Culture and maternal mental health SACP Toronto 2013.
• Invited Speaker: Husain N Culture & Self Harm in British South Asians from Epidemiology to Intervention. Berlin February 2012.
• Speaker: Chaudhry N, & Husain N. Culturally competent treatment of depression: an example from Manchester. EACLPP Budapest 2011.
• Speaker: Husain N & Chaudhry IB. Culturally adapted manual assisted problem solving training (C-MAPS) for prevention of self-harm: An RCT from a low income country. EACLPP Budapest 2011.
• Speaker: Husain N & Chaudhry N: Medically Unexplained Symptoms and Quality of Life in Pakistanis in UK and in Pakistan. Noordwijkerhout (2009).
• Speaker: Chaudhry N & HusainN: Do people of Pakistani origin have more somatic symptoms of depression than white Europeans. Noordwijkerhout (2009).
• Invited Speaker: Husain N: Developing Services for Canadian South Asians. Lessons from the UK. Mood Disorder Programme, Centre for Addiction & Mental Health, UFT, Toronto (2009).
• Invited Speaker: Husain N: Learning Through Play & Postnatal depression in fathers: Findings from a low income country. International conference organized by the Hincks Dellcrest Centre, University of Toronto. Toronto (2009).
• Invited Speaker: Husain N: Depression in South Asians in UK: From Epidemiology to Intervention. Centre for International Mental Health University of Melbourne (2008).
Key Note Speaker: Husain N: Psychosocial treatment of depression: Learning from Pakistan. Inaugural meeting of Centre in Africa for Learning and Living. Mombasa (2007).
• Speaker: Husain N: Irritable Bowel Syndrome in a Low income country. Depressive symptoms, treatment seeking & disability. World Psychiatric Association Nairobi (2007).
Key Note Speaker: Husain N “Maternal depression and malnourished children, is there a link?” International conference organized by the Hincks Dellcrest Centre, University of Toronto. Toronto (2006).
• Speaker: Husain N: Social origins of depression in Pakistani women. XIII World Congress of Psychiatry, 5000 years of Science & Care, Building the Future of Psychiatry. World Psychiatric Association Cairo (2005).
• Invited Speaker: Husain N: Social Correlates of depression in Pakistani women in Pakistan and women of Pakistani origin in the UK. 2nd International conference on Culture & Mental Health. Toronto (2005).
• Speaker: Husain N: Social Stress and depression in women in Pakistan. 13th Congress Association of European Psychiatrists Munich (2005).
• Invited Speaker: Husain N: Chronic Difficulties & Depression in British Pakistanis. Ninth International Metropolis Conference. Geneva (2004).
• Invited Speaker: Husain N: Chronic difficulties and persistent depression. World Psychiatric Association Regional Symposium Lahore (2004).